What question did this study set out to answer?

This research aims to identify demographic and clinical variables linked to responses to clozapine in patients with treatment-resistant schizophrenia.

February 1, 2021Psychological MedicineOpen Access

Demographic and clinical variables associated with response to clozapine in schizophrenia: a systematic review and meta-analysis

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Authors

KGKira GriffithsLiberating Technologies (United States)EMEdward MillgateThe King's College AEAlice EgertonKing's College London

Discussion

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Implication

Systematic review evaluates clozapine response factors in treatment-resistant schizophrenia, suggesting earlier treatment initiation may improve outcomes.

Key Points

This research aims to identify demographic and clinical variables linked to responses to clozapine in patients with treatment-resistant schizophrenia.
Conducted a systematic review of literature on clozapine response factors.
Performed a random-effects meta-analysis on demographic and clinical variables among responders and non-responders.
Reviewed 31 articles qualitatively and 17 quantitatively, focusing on factors like duration of illness and age at clozapine initiation.
Clozapine responders had a significantly shorter duration of illness compared to non-responders (g = 0.31; 95% CI 0.06-0.56; p = 0.01).
Younger age at clozapine initiation and fewer hospitalizations were associated with better response.
Results suggest timely initiation of clozapine may lead to improved patient outcomes.

Cite This Study

Griffiths et al. (2021) studied this question.

synapsesocial.com/papers/6a34dcee86769fa257ffa2f9 https://doi.org/10.1017/s0033291721000246

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February 1, 2021Psychological MedicineOpen Access

Demographic and clinical variables associated with response to clozapine in schizophrenia: a systematic review and meta-analysis

View Full Paper

Ask AI

Bookmark

Authors

KGKira GriffithsLiberating Technologies (United States)EMEdward MillgateThe King's College AEAlice EgertonKing's College London

Discussion

Member takes

Implication

Systematic review evaluates clozapine response factors in treatment-resistant schizophrenia, suggesting earlier treatment initiation may improve outcomes.

Key Points

This research aims to identify demographic and clinical variables linked to responses to clozapine in patients with treatment-resistant schizophrenia.
Conducted a systematic review of literature on clozapine response factors.
Performed a random-effects meta-analysis on demographic and clinical variables among responders and non-responders.
Reviewed 31 articles qualitatively and 17 quantitatively, focusing on factors like duration of illness and age at clozapine initiation.
Clozapine responders had a significantly shorter duration of illness compared to non-responders (g = 0.31; 95% CI 0.06-0.56; p = 0.01).
Younger age at clozapine initiation and fewer hospitalizations were associated with better response.
Results suggest timely initiation of clozapine may lead to improved patient outcomes.

Cite This Study

Griffiths et al. (2021) studied this question.

synapsesocial.com/papers/6a34dcee86769fa257ffa2f9 https://doi.org/10.1017/s0033291721000246

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