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This is a Case Report study (also classified as: Literature Review).

September 16, 2025European PsychiatryOpen Access

Use of High-Dose Sertraline for Obsessive-Compulsive Disorder: A Case Report

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Case report finds high-dose sertraline effectively reduces OCD symptoms in a 50-year-old woman, suggesting new treatment options.

High-dose sertraline led to near-complete symptom resolution in the patient after four months of treatment.
The patient’s Y-BOCS scores improved from 31 at baseline to 13, indicating significant reduction in OCD severity.
Despite initial tolerance issues with added medications, sertraline monotherapy proved effective for treatment-resistant OCD.
High-dose sertraline shows promise but requires careful consideration of individual responses to treatment.

Fernández et al. (2025) studied this question.

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