What question did this study set out to answer?

Summarize the dose–response relationship and determine the optimal dose of serotonin reuptake inhibitors for treating adult obsessive-compulsive disorder.

September 23, 2021Frontiers in PsychiatryOpen Access

Optimal Dose of Serotonin Reuptake Inhibitors for Obsessive-Compulsive Disorder in Adults: A Systematic Review and Dose–Response Meta-Analysis

View Full Paper

Ask AI

Bookmark

Authors

JXJiao XuTianjin University of Traditional Chinese Medicine QHQinjian HaoSichuan University RQRuiyi QianShanghai Mental Health Center

Discussion

Member takes

Implication

Dose-response meta-analysis finds that 40 mg fluoxetine equivalents maximizes efficacy for adult obsessive-compulsive disorder, indicating that higher doses increase adverse effects without extra...

Key Points

Summarize the dose–response relationship and determine the optimal dose of serotonin reuptake inhibitors for treating adult obsessive-compulsive disorder.
Systematic review of 11 studies (N=2,322 participants) identified across Medline, Embase, Biosis, PsycINFO, CENTRAL, Web of Science, and CINAHL up to February 22, 2020.
Doses were converted to fluoxetine equivalents and evaluated via a one-stage robust error meta-regression (REMR) model (PROSPERO CRD42020168344).
The dose–efficacy curve increased gradually across the 0–40 mg fluoxetine equivalent range and showed a declining trend at doses up to 100 mg.
Dropouts due to adverse effects increased steadily across the entire dose spectrum, whereas all-cause dropouts showed no association with dose.

Cite This Study

Xu et al. (2021) studied this question.

synapsesocial.com/papers/6a87a7bd9018e99caaf3020b https://doi.org/10.3389/fpsyt.2021.717999

View Full Paper

Ask AI

Bookmark

Implication

Dose-response meta-analysis finds that 40 mg fluoxetine equivalents maximizes efficacy for adult obsessive-compulsive disorder, indicating that higher doses increase adverse effects without extra...

Optimal Dose of Serotonin Reuptake Inhibitors for Obsessive-Compulsive Disorder in Adults: A Systematic Review and Dose–Response Meta-Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Optimal Dose of Serotonin Reuptake Inhibitors for Obsessive-Compulsive Disorder in Adults: A Systematic Review and Dose–Response Meta-Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider