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September 16, 2025European PsychiatryOpen Access

Probiotics decrease C-reactive protein level in depression depending on basal chronic low-grade inflammation status or antidepressant use – secondary results of the Pro-demet randomized clinical trail

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Authors

OGOliwia Gawlik-KotelnickaAWAdam WysokińskiAGAlina Gajewska

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Overview

Randomized clinical trial shows probiotics decrease C-reactive protein in depression, indicating potential adjunctive therapy based on inflammation status.

Key Points

  • Probiotics significantly reduced C-reactive protein levels by 21.3% compared to placebo.
  • The proportion of responders achieving a 50% decrease in CRP was 18.0% in the probiotic group versus 5.26% in placebo.
  • Probiotic effectiveness was enhanced by antidepressant use and higher basal alanine aminotransferase levels.
  • Chronic low-grade inflammation status impeded the anti-inflammatory effects of probiotics.

Cite This Study

Gawlik-Kotelnicka et al. (2025) studied this question.

synapsesocial.com/papers/68d4507d31b076d99fa57fb1https://doi.org/10.1192/j.eurpsy.2025.2028
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Probiotics Decrease C-Reactive Protein Levels in Depression Depending on Metabolic Syndrome Presence or Antidepressant Treatment – Secondary Results of a Randomized Clinical Trial2025
  2. 2Examining immune-inflammatory mechanisms of probiotic supplementation in depression: secondary findings from a randomized clinical trial2024 · 11 citations
  3. 3Examining immune-inflammatory mechanisms of probiotic supplementation in depression: secondary findings from a randomized clinical trial2024
  4. 4Metabolic Status Influences Probiotic Efficacy for Depression—PRO-DEMET Randomized Clinical Trial Results2024 · 10 citations
  5. 5The effectiveness of a Lactobacillus probiotic on measures of psychosocial health in adults diagnosed with subthreshold depression: a double-blind, randomised, placebo-controlled trial2024 · 3 citations