Supplementary Figure S1 from Phase Ib Study of Pembrolizumab in Combination with Intratumoral Injection of Clostridium novyi-NT in Patients with Advanced Solid Tumors

Key Points

Systemic tumor antigen specific T-cell responses increased significantly with the treatment combination.
Key evidence indicates enhanced T-cell activity in patients with advanced solid tumors receiving pembrolizumab.
Observational analysis assessed the efficacy of intratumoral injection of clostridium novyi-NT combined with pembrolizumab.
Results may enable further research into innovative combination therapies for cancer treatment.

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Phase Ib study shows effective T-cell responses in advanced solid tumors, suggesting potential for this combination treatment.

Supplementary Figure S1. Systemic tumor antigen specific T-cell responses.

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Nelson et al. (2025) studied this question.

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