Supplementary Figure S2 from Tumor Immune Microenvironment–Associated Prognostic and Mifamurtide-Response Gene Signatures for Localized Osteosarcoma: A Correlative Study of the ISG/OS-2 Trial

Emanuela Palmerini; Maria Rosaria Sapienza; Stefano Pileri; Giorgio Frega; Alberto Righi; Antonina Parafioriti; Alessandro Franchi; Claudio Agostinelli; Simona Righi; Cristina Meazza; Virginia Ferraresi; Sebastian Dorin Asaftei; Luca Coccoli; Angela Tamburini; Marco Gambarotti; Massimo Serra; Davide María Donati; Franca Fagioli; Marilena Cesari; Elisa Carretta; Katia Scotlandi; Toni Ibrahim; Maria Antonella Laginestra

doi:10.1158/1078-0432.30125623

Key Points

Overall survival did not significantly differ between Pgp-positive and Pgp-negative patients.
Median follow-up was 107.8 months for the study cohort of 62 localized osteosarcoma patients.
Prognostic gene signatures related to the immune microenvironment were assessed in the study.
Findings suggest potential implications for patient management in localized osteosarcoma.

Implication

Correlative analysis shows overall survival rates in localized osteosarcoma patients, indicating gene signatures may guide treatment decisions.

Abstract

Supplementary Figure S2:Overall survival of 62 patients with localized osteosarcoma (A) after a median follow-up of 107.8 months (IQR:92.5–128.4). (B) Overall survival for the 62 patients considered in the present study stratified as Pgp-positive and Pgp-negative (p = 0.6990).

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Cite This Study

Palmerini et al. (2025) studied this question.

synapsesocial.com/papers/68d4538731b076d99fa588fc https://doi.org/10.1158/1078-0432.30125623

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Supplementary Figure S2 from Tumor Immune Microenvironment–Associated Prognostic and Mifamurtide-Response Gene Signatures for Localized Osteosarcoma: A Correlative Study of the ISG/OS-2 Trial

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S2 from Tumor Immune Microenvironment–Associated Prognostic and Mifamurtide-Response Gene Signatures for Localized Osteosarcoma: A Correlative Study of the ISG/OS-2 Trial

Key Points

Implication

Abstract

Discussion

Cite This Study

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