Supplementary Figure S5 from Tumor Immune Microenvironment–Associated Prognostic and Mifamurtide-Response Gene Signatures for Localized Osteosarcoma: A Correlative Study of the ISG/OS-2 Trial

This is a Quantitative Study study.

Key Points

CIBERSORTx analysis revealed specific immune cell compositions associated with localized osteosarcoma, shedding light on tumor microenvironment
Among 62 osteosarcoma samples, significant variations in immune cell types were detected, indicating potential prognostic implications
The analysis employed CIBERSORTx for evaluating cell fractions in tumor samples, enabling better understanding of immune interactions
Findings suggest that immune microenvironment profiling may enhance prognosis evaluations and inform Mifamurtide treatment strategies

Correlative analysis explores prognostic gene signatures and immune cell composition in osteosarcoma, suggesting potential therapeutic targets.

Supplementary Figure S5: CIBERSORTx output of cell fraction deconvolution in the 62 primary Osteosarcoma of the discovery set.

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Palmerini et al. (2025) studied this question.

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