Supplementary Figure S3 from Biomarker Analysis and Treatment Dynamics Following Preoperative Ipilimumab plus Nivolumab in Locally Advanced Urothelial Cancer from the Phase IB NABUCCO Study

Key Points

Responders showed distinct patterns in DDR gene mutations compared to non-responders, indicating potential for personalized treatment.
The study highlights significant differences in treatment arms for DNA damage response gene alterations.
Preoperative treatment with ipilimumab and nivolumab reveals important insights into therapeutic outcomes for urothelial cancer.
Findings advocate for further investigation into the role of DDR genes in treatment dynamics and efficacy.

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Phase IB NABUCCO study analyzes treatment responses linked to DDR gene alterations in urothelial cancer.

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Stockem et al. (2025) studied this question.

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