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Synapse
September 16, 20250 citations

Biomarker Analysis and Treatment Dynamics in Urothelial Cancer with Ipilimumab and Nivolumab

Supplementary Figure S3 from Biomarker Analysis and Treatment Dynamics Following Preoperative Ipilimumab plus Nivolumab in Locally Advanced Urothelial Cancer from the Phase IB NABUCCO Study

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Authors

CSChantal F. StockemAGAlberto Gil-JimenezHAHamza Ali

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Overview

Phase IB NABUCCO study analyzes treatment responses linked to DDR gene alterations in urothelial cancer.

Key Points

  • Responders showed distinct patterns in DDR gene mutations compared to non-responders, indicating potential for personalized treatment.
  • The study highlights significant differences in treatment arms for DNA damage response gene alterations.
  • Preoperative treatment with ipilimumab and nivolumab reveals important insights into therapeutic outcomes for urothelial cancer.
  • Findings advocate for further investigation into the role of DDR genes in treatment dynamics and efficacy.

Cite This Study

Stockem et al. (2025) studied this question.

synapsesocial.com/papers/68d4538731b076d99fa58954https://doi.org/10.1158/1078-0432.30125719
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