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E3 ligase MKRN2 destabilizes PPP2CA proteins to inactivate canonical Wnt pathway and mitigates tumorigenesis of clear cell renal cell carcinoma

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Analysis reveals MKRN2 inactivates the Wnt pathway in clear cell renal cell carcinoma, indicating tumor suppression.

Down-regulation of mkRN2 in ccRCC tissues correlates with promoter DNA hypermethylation.
Overexpression of mkRN2 leads to reduced tumor growth and better clinical outcomes.
MKRN2 promotes ubiquitination of ppp2ca, resulting in decreased β-catenin levels and Wnt pathway inactivation.
This research identifies mkRN2 as a potential candidate tumor suppressor in clear cell renal cell carcinoma.

Yu et al. (2025) studied this question.

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