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This is a Experimental Study study.

September 16, 2025European PsychiatryOpen Access

Involvement of inflammation in pathogenesis of autism spectrum disorders: experimental model of postnatal valproic acid administration

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Authors

АСА. А. СтахановаLomonosov Moscow State University OVO.G. VoskresenskayaLomonosov Moscow State University SZS. A. ZozulyaAcademy of Medical Sciences

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Implication

Experimental model reveals valproic acid alters behavior and leukocyte elastase activity in rats, suggesting inflammation's role in autism spectrum disorders.

Key Points

Postnatal administration of valproic acid significantly alters weight gain and behavioral characteristics in rats.
Behavioral tests showed delayed social interactions in valproic acid-treated rats compared to controls, indicating impaired social behavior.
Leukocyte elastase activity in the blood serum was higher in rats receiving valproic acid, suggesting a link with inflammation in autism spectrum disorders.
The findings support the validity of using valproic acid as a model for studying neuroinflammation in autism.

Cite This Study

Стаханова et al. (2025) studied this question.

synapsesocial.com/papers/68d454cb31b076d99fa5a3f8 https://doi.org/10.1192/j.eurpsy.2025.1703

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Implication

Experimental model reveals valproic acid alters behavior and leukocyte elastase activity in rats, suggesting inflammation's role in autism spectrum disorders.

Involvement of inflammation in pathogenesis of autism spectrum disorders: experimental model of postnatal valproic acid administration

Discussion

Member takes

Implication

Key Points

Cite This Study

Involvement of inflammation in pathogenesis of autism spectrum disorders: experimental model of postnatal valproic acid administration

Discussion

Member takes

Implication

Key Points

Cite This Study

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