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Valproic Acid Exposure During the Brain Growth Spurt Leads to Autistic‐Like Behaviours in Mice

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Investigation reveals valproic acid exposure affects anxiety-like behaviour and sociability in mice, suggesting risks for autism spectrum disorder.

Adolescent mice exposed to valproic acid showed increased anxiety-like behaviours and lower sociability.
Hyperactivity was also observed in the VPA group, alongside higher serotonin levels in serum.
Mice tested during adolescence exhibited neurobehavioural deficits linked to autism spectrum disorder.
Early VPA exposure during the brain growth spurt appears to be critical for developing these behaviours.

Denucci et al. (2025) studied this question.

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Investigation reveals valproic acid exposure affects anxiety-like behaviour and sociability in mice, suggesting risks for autism spectrum disorder.