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Evaluation of Metformin Plus Insulin Versus Insulin-Only in Preventing Pre-Eclampsia in Pregnant Women with Gestational Diabetes Mellitus: A Randomized Single-Blind Clinical Trial

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Randomized trial shows combined metformin and insulin reduces proteinuria in pregnant women with GDM, suggesting better outcomes.

Adding metformin to insulin therapy results in lower proteinuria rates for women with gestational diabetes.
The insulin dose required for the metformin group was significantly less than for the insulin-only group.
This randomized clinical trial involved 150 women from Isfahan, evaluating diabetes treatment effectiveness.
Inclusion of metformin did not increase other pregnancy complications in the studied population.

Koupaei et al. (2025) studied this question.

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