What question did this study set out to answer?

This study aims to evaluate whether adding metformin to medical nutrition therapy reduces the progression to gestational diabetes in women with early gestational glucose intolerance.

August 3, 2026BMC Pregnancy and ChildbirthOpen Access

Prevention of GDM by treating early gestational glucose intolerance with and without metformin: a randomized controlled trial

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Authors

PSPikee SaxenaLady Hardinge Medical College STSrilekha ThupiliLady Hardinge Medical College VSV SeshiahTamil Nadu Dr. M.G.R. Medical University

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Implication

Randomized trial shows metformin significantly reduces progression to gestational diabetes in women with early glucose intolerance, highlighting potential benefits for pregnancy outcomes.

Key Points

This study aims to evaluate whether adding metformin to medical nutrition therapy reduces the progression to gestational diabetes in women with early gestational glucose intolerance.
Randomized controlled trial involving 220 pregnant women with early gestational glucose intolerance identified before 9 weeks of gestation.
Participants received either medical nutrition therapy plus metformin or medical nutrition therapy alone.
Maternal and neonatal outcomes were assessed, using multivariable Poisson regression to estimate adjusted risk ratios.
Progression to gestational diabetes was significantly lower in the metformin group (2.73%) compared to the MNT-only group (84.55%; aRR 0.036, 95% CI 0.012–0.106; p < 0.0001).
The metformin group had lower risks of hypertension, polyhydramnios, and admissions to the neonatal intensive care unit compared to the MNT group.
Associations with improved outcomes remained significant after controlling for potential confounders.

Cite This Study

Saxena et al. (2026) studied this question.

synapsesocial.com/papers/6a70402f75942ff7265e4f6b https://doi.org/10.1186/s12884-026-09685-y

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Implication

Randomized trial shows metformin significantly reduces progression to gestational diabetes in women with early glucose intolerance, highlighting potential benefits for pregnancy outcomes.

Prevention of GDM by treating early gestational glucose intolerance with and without metformin: a randomized controlled trial

Discussion

Member takes

Implication

Key Points

Cite This Study

Prevention of GDM by treating early gestational glucose intolerance with and without metformin: a randomized controlled trial

Discussion

Member takes

Implication

Key Points

Cite This Study

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