The Correlation between HOMA-IR, QUICKI and HbA1c as predictors of type 2 diabetes in a Moroccan population

Introduction : HOMA-IR and QUICKI are indexes that estimate insulin resistance and sensitivity. Objective : This study assesses their correlation with HbA1c to determine their potential as predictors of type 2 diabetes. Material and methods : The study group comprise 91 subjects divided into three subgroups: G0 (n=52) healthy individuals, G1 (n=21) subjects with controlled T2DM and G2 (n=18) subjects with unbalanced T2DM. The HOMA-IR and QUICKI indices are calculated using a mathematical formula based on fasting blood glucose and insulin levels. Results : The correlation between HbA1c and HOMA-IR showed a significant correlation in all 3 groups of patients : G0 (r = 0.47, p < 10-3), G1 (r = 0.42, p = 0,05) et G2 (r = 0.81, p < 10-3). Moderate correlations were found in groups G0 and G1 : G0 (r = 0.47, p < 10-3), G1 (r = 0.42, p =0,05). A weak correlation was found in group G2. Conclusion : HOMA-IR and QUICKI show potential as early indicators of the onset of type 2 diabetes. Their use could improve the screening.