This analysis reveals a mechanism linking cellular prion protein and renal fibrosis in CKD, suggesting new therapeutic targets.
Renal fibrosis, the common pathological endpoint of Chronic Kidney Disease (CKD), represents a global health challenge due to its high prevalence and limited therapeutic options [1]. Despite its clinical significance, the molecular mechanisms driving this process remain poorly understood. In a landmark cover study published in Science Translational Medicine, Long et al. identified a novel mechanism by which cellular prion protein (PrPC) drives renal fibrosis through Liquid- Liquid Phase Separation (LLPS).
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Zou et al. (2025) studied this question.
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