Case report reveals unusual facial hyperpigmentation in vitamin B12 deficiency, suggesting its possible mimicry of Addison's disease.
Vitamin B12 deficiency can manifest in various forms, including skin changes in the form of hyperpigmentation. The hyperpigmentation in vitamin B12 deficiency commonly presents over the hands and feet, but presenting over the face and oral cavity is very rare. Here we describe an interesting case where there was hyperpigmentation in the face and oral cavity which was mimicking Addison's disease, but the actual diagnosis was vitamin B12 deficiency. This case stresses that knowing the uncommon manifestations of common disease is more important than knowing the common manifestations of uncommon disease.
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Ram Arvind Viswanathan (2025) studied this question.
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