What question did this study set out to answer?

This research aims to explore isolated palmar hyperpigmentation as a rare presentation of vitamin B12 deficiency.

June 23, 2026Open Access

Isolated Palmar Hyperpigmentation: Rare Presentation of B12 Deficiency

MSMukti Nath SankhiNepalese Army Institute of Health Services RSRajiv SitaulaBir Hospital SSSamir SamadarshiSouthern Command Hospital

Key Points

This research aims to explore isolated palmar hyperpigmentation as a rare presentation of vitamin B12 deficiency.
Descriptive case analysis of patients with vitamin B12 deficiency.
Clinical assessment of hyperpigmentation patterns, including isolated palmar areas.
Evaluation of additional vitamin B12 deficiency symptoms related to anemia and neurologic features.
Isolated palmar hyperpigmentation occurs without the typical knuckle hyperpigmentation.
Patients exhibited no other common symptoms, such as smooth tongue or anemia.
The unique manifestation of isolated palmar hyperpigmentation challenges standard diagnostic approaches.

Abstract

ABSTRACT Vitamin B12 deficiency has a myriad of presentations. Skin hyperpigmentation, especially at the knuckles, is common. However, in rare instances, a patient may present with isolated palmar hyperpigmentation instead of the usual features, such as knuckle hyperpigmentation, smooth tongue, symptoms related to anemia, and neurologic features.

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Cite This Study

Sankhi et al. (Mon,) studied this question.

synapsesocial.com/papers/6a3a225d111626ef22ab6fd8 https://doi.org/https://doi.org/10.1002/ccr3.73013

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