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September 17, 2025Problems of VirologyOpen Access

Vpr, accessory protein of human immunodeficiency virus type 1 (Retroviridae: Orthoretrovirinae: Lentivirus: Human immunodeficiency virus-1): features of genetic variants of the virus circulating in the Moscow region in 2019–2020

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Authors

AKAnna KuznetsovаAAAnastasiia AntonovaEMEkaterina A. Makeeva

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Overview

Analysis reveals the influence of vpr genetic variants on HIV-1 oligomerisation in patients, suggesting therapeutic potential.

Key Points

  • Vpr protein influences oligomeric forms of HIV-1 variations, impacting function and possible treatment strategies.
  • No significant differences in amino acid substitution rates were observed among patients at different disease stages.
  • Proviral DNA extraction and sequencing of vpr variants were performed on 231 HIV-1 samples from 2019-2020.
  • Findings highlight Vpr-A6 variants' low variability, suggesting their potential as therapeutic targets against HIV-1.

Cite This Study

Kuznetsovа et al. (2025) studied this question.

synapsesocial.com/papers/68d4567431b076d99fa5bdd7https://doi.org/10.36233/0507-4088-296
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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  4. 4Vpr Is Required for Efficient Replication of Human Immunodeficiency Virus Type-1 in Mononuclear Phagocytes1995 · 1,288 citations
  5. 5A Pilot Investigation of the Association Between Vpr Amino Acid Substitutions and Peripheral Immune Marker Levels in People With Human Immunodeficiency Virus: Implications for Neurocognitive Impairment2024 · 3 citations