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September 17, 2025Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

Thigh Fat to Muscle Ratio on MRI is Related to Alzheimer’s Disease Neurodegeneration in Midlife Obesity

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Authors

MNMahshid NaghashzadehPCPaul K. CommeanMDMahsa Dolatshahi

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Overview

Study shows thigh fat-to-muscle ratio is associated with cortical thickness in Alzheimer disease, suggesting its role in early risk assessment.

Key Points

  • Higher thigh fat-to-muscle ratio correlates with reduced cortical thickness in Alzheimer's-related brain regions.
  • Weight and insulin resistance are positively correlated with increased thigh fat-to-muscle ratio and cognitive decline.
  • Analysis controlled for age and sex, highlighting the precision of MRI in assessing brain health.
  • Identifying high thigh fat-to-muscle ratio could enable targeted interventions to improve metabolic health in midlife.

Cite This Study

Naghashzadeh et al. (2025) studied this question.

synapsesocial.com/papers/68d4596631b076d99fa5c162https://doi.org/10.58530/2025/2876
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