What question did this study set out to answer?

To explore how different types of body fat relate to Alzheimer's disease markers in middle-aged individuals.

June 8, 2026Journal of Alzheimer s Disease

Abdominal adiposity and Alzheimer's disease imaging markers across sex and race at midlife

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Authors

MDMahsa DolatshahiWashington University in St. Louis PCPaul K. CommeanWashington University in St. Louis MNMahshid NaghashzadehWashington University in St. Louis

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Implication

Randomized trial investigates connections between body fat and Alzheimer's imaging markers at midlife, suggesting crucial implications for prevention.

Key Points

To explore how different types of body fat relate to Alzheimer's disease markers in middle-aged individuals.
Ninety-seven cognitively normal individuals underwent brain imaging and metabolic assessments.
Key measures included MRI-derived adipose tissue volumes and cognitive evaluations.
Correlations between adiposity metrics and Alzheimer's pathology were analyzed.
Visceral adipose tissue (VAT) showed a significant correlation with amyloid burden (rho = 0.36, p = 0.002) in females and Whites.
Lower high-density lipoprotein (HDL) cholesterol was linked to amyloid pathology irrespective of sex and race (rho = -0.36, p = 0.002).
VAT/SAT ratio was significantly associated with tau pathology (β = 0.138, p = 0.030) after adjustments.

Cite This Study

Dolatshahi et al. (2026) studied this question.

synapsesocial.com/papers/6a265ca8ad53cfb9357c5e4e https://doi.org/10.1177/13872877261455657

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Implication

Randomized trial investigates connections between body fat and Alzheimer's imaging markers at midlife, suggesting crucial implications for prevention.

Abdominal adiposity and Alzheimer's disease imaging markers across sex and race at midlife

Discussion

Member takes

Implication

Key Points

Cite This Study

Abdominal adiposity and Alzheimer's disease imaging markers across sex and race at midlife

Discussion

Member takes

Implication

Key Points

Cite This Study

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