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December 18, 2016The Journals of Gerontology Series AOpen Access

Associations of Brain Structure With Adiposity and Changes in Adiposity in a Middle-Aged and Older Biracial Population

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Why the study?

Is adiposity and its change associated with white matter hyperintensities and total brain volume in a middle-aged and older biracial population?

Population

1,702 participants from the Genetic Epidemiology Network of Arteriopathy study, mean age 57 at Visit 1 and…

Design

Cohort

Follow-up

mean 5.2 years

Authors

BWB. Gwen WindhamPreventive CardiologySLSeth T. LiretteJackson Memorial HospitalMFMyriam FornagePennington Biomedical Research Center

Discussion

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Implication

Higher BMI tied to lower TBV in AA and NHW; leaves open whether adiposity modification affects brain aging.

Structured PICO

Is adiposity and its change associated with white matter hyperintensities and total brain volume in a middle-aged and older biracial population?

P
Population
1,702 participants from the Genetic Epidemiology Network of Arteriopathy study (64% women, 48% African American), mean age 57 at Visit 1 and 61 at Visit 2.
I
Intervention
Adiposity (body mass index and waist circumference) and changes in adiposity over a mean of 5.2 years
O
Outcome
White matter hyperintensities (WMH) and total brain volume (TBV) measured by brain MRIsurrogate

Higher adiposity and increases in BMI during mid-life are associated with lower total brain volume, particularly in African Americans, suggesting detrimental effects on brain health.

Cite This Study

Windham et al. (2016) studied this question.

synapsesocial.com/papers/6a7598fb3d78a07d47dd7705https://doi.org/10.1093/gerona/glw239

Topics

Hypertension management
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