Key result
Higher visceral-to-subcutaneous fat ratio links to greater precuneus amyloid uptake in cognitively normal midlife adults.
Why the study?
Obesity and excess adiposity at midlife are risk factors for Alzheimer disease, but the associations of abdominal adiposity and insulin resistance with amyloid and tau uptake and neurodegeneration were uncharacterized.
Is visceral obesity and insulin resistance associated with Alzheimer disease pathology and neurodegeneration in cognitively normal midlife adults?
Cross-Sectional (n=32)
No
Is visceral obesity and insulin resistance associated with Alzheimer disease pathology and neurodegeneration in cognitively normal midlife adults?
Effect estimate: rho=0.55
p-value: p=0.034
In cognitively normal midlife adults, higher visceral obesity is associated with increased amyloid pathology and lower cortical thickness in Alzheimer disease-signature areas.
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Visceral obesity may mark early amyloid risk in midlife; leaves open causality and precludes practice change.
Dolatshahi et al. (2023) conducted a cross-sectional in Cognitively normal midlife adults (n=32). Visceral-to-subcutaneous fat ratio (VAT/SAT ratio) was evaluated on PiB SUVR in the right precuneus cortex (rho=0.55, p=0.034). In cognitively normal midlife adults, a higher visceral-to-subcutaneous fat ratio was significantly associated with increased amyloid uptake in the right precuneus cortex (rho=0.55, p=0.034).
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