Key result
Obesity with insulin resistance was associated with lower right entorhinal white matter volumes (p=0.004), and higher visceral-to-subcutaneous fat ratio correlated with amyloid uptake (p=0.005).
Why the study?
Midlife obesity is a known risk factor for Alzheimer disease, but the associations of brain MRI volumes and amyloid and tau uptake with obesity, insulin resistance, and abdominal adipose tissue in cognitively normal individuals needed evaluation.
Population
34 middle-aged cognitively normal participants
Comparison
Associations with obesity, insulin resistance, and abdominal adipose tissue
Design
Cross-sectional study
Authors
Loading...
May link visceral adiposity to early AD changes; leaves open causality and clinical relevance in cognitively normal adults.
Cross-Sectional (n=34)
Effect estimate: R2 0.31
p-value: p=0.004
In cognitively normal midlife individuals, visceral obesity and insulin resistance are associated with early amyloid pathology and lower entorhinal white matter volume, suggesting a link between metabolic health and Alzheimer's disease risk.
Dolatshahi et al. (2023) conducted a cross-sectional in Cognitively normal (n=34). Obesity with insulin resistance and visceral adiposity vs. Metabolically normal non-obese individuals was evaluated on Brain MRI volumes and amyloid/tau SUVRs within the default mode network areas (R2 0.31, p=0.004). Obesity with insulin resistance was associated with lower right entorhinal white matter volumes (p=0.004), and higher visceral-to-subcutaneous fat ratio correlated with amyloid uptake (p=0.005).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: