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The study investigates how abdominal fat and systemic inflammation relate to neuroinflammation in midlife obesity.

November 8, 2024ObesityOpen Access

Relationships between abdominal adipose tissue and neuroinflammation with diffusion basis spectrum imaging in midlife obesity

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Randomized trial examines links between obesity and neuroinflammation in midlife individuals, suggesting health implications.

The study investigates how abdominal fat and systemic inflammation relate to neuroinflammation in midlife obesity.
Analyzed data from 98 cognitively normal midlife participants (mean age 49.4).
Conducted brain and abdominal MRI, blood tests, and amyloid PET imaging.
Assessed white matter differences using tract-based spatial statistics and diffusion basis spectrum imaging.
Obesity and high abdominal fat linked to lower axial diffusivity and reduced fiber fraction in white matter.
Higher C-reactive protein correlates with lower axial diffusivity, suggesting increased inflammation.
BMI and subcutaneous adipose tissue affect restricted fractions, especially in males.

Dolatshahi et al. (2024) studied this question.

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