Why the study?
Midlife obesity is a risk factor for late-onset Alzheimer disease, but the underlying mechanisms remain unknown.
Population
166 asymptomatic individuals (38–71 years old)
Comparison
Central obesity and systemic inflammatory markers vs limbic microstructure
Authors
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Visceral adiposity may affect fornix integrity via adipokines; hypothesis-generating for Alzheimer's pathways, requiring longitudinal confirmation.
Visceral fat-related systemic inflammation may damage myelin-related properties of the fornix, potentially contributing to late-onset Alzheimer's disease risk.
Metzler‐Baddeley et al. (2019) studied this question.
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