Observational analysis mapped metabolic changes in the developing brain of rats with chronic liver disease, indicating 1H-FID-MRSI's potential for tracking regional differences.
Motivation: Type C hepatic encephalopathy (HE) is increasingly suspected in children with chronic liver disease (CLD) and various brain regions might be affected. Goal(s): To investigate the potential of 1H-FID-MRSI to detect metabolic and brain regional changes in a model of CLD during brain development and maturation. Approach: Bile duct ligated and sham rats operated at p21 days after birth underwent 1H-FID-MRSI 6-weeks post-ligation at 9.4T. Results: Using 1H-FID-MRSI, we detected and mapped the metabolic changes in the developing brain with CLD, investigated brain regional changes, and proved the potential of 1H-FID-MRSI to detect small changes due to individual animal response to disease. Impact: Our study demonstrated the potential of 1H-FID-MRSI at 9.4T to detect and map metabolic changes in the developing brain in a rat model of chronic liver disease, specifically regional differences and changes in Gln due to individual response to disease.
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Nossa et al. (2025) studied this question.
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