Exploring functional connectivity differences in upright and supine positions, indicating posture affects brain activity.
Motivation: An important but underexplored confound in fMRI is body posture. Goal(s): Exploring the Impact of Standing and Lying Positions on Brain Resting-State Functional Connectivity Imaging. Approach: 29 healthy volunteers underwent multi-position helium-free 1.5T MRI (XGY Spin 1.5T MRI) scans. The scan sequences included upright fMRI and supine 3D T1WI and fMRI. A comparison of functional connectivity metrics between the upright and supine fMRI was conducted. Results: Compared to the supine position, the ALFF values of multiple brain regions were altered in the upright position. The upright position led to changes in whole-brain and default mode network (DMN) connectivity compared to the supine position. Impact: Multi-position helium-free 1.5T MRI helps investigate the functional states of various diseases in daily upright posture. It opens a new chapter in brain science research.
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Zhang et al. (2025) studied this question.
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