An analysis demonstrates the relationship between omega-3 PUFAs and myocardial strain in hypertensive patients, suggesting caution in supplementation.
Motivation: The impact of omega-3 polyunsaturated fatty acids (PUFAs) on cardiovascular disease is a prominent research focus, but recent studies have produced inconsistent findings. Goal(s): This study used cardiac magnetic resonance feature tracking (CMR-FT) to analyze the relationship between blood levels of omega-3 PUFAs and left atrial and left ventricular myocardial strain in hypertensive patients, thereby assessing the impact of omega-3 PUFAs on left heart function. Approach: The study utilized b-SSFP cine sequences, CVI42 software, Spearman correlation analysis, and multivariate linear regression analysis. Results: Elevated omega-3 PUFAs levels may impair left heart myocardial strain in hypertensive patients. Impact: These findings highlight a potential need for caution in the use of omega-3 PUFAs supplements for primary cardiovascular disease prevention, considering uncertain cardiovascular benefits. The results also provide imaging evidence to support early clinical intervention.
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Cui et al. (2025) studied this question.
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