Key result
In hypertensive patients, circulating ω-3 polyunsaturated fatty acid levels were independently associated with impaired left cardiac myocardial strain, with total ω-3 predicting left atrial dysfunction (AUC 0.629).
Why the study?
To assess the association between circulating polyunsaturated fatty acids and left cardiac myocardial strain in hypertensive patients using cardiac magnetic resonance feature tracking.
Are circulating ω-3 polyunsaturated fatty acid levels associated with impaired left cardiac myocardial strain in hypertensive patients with preserved LVEF?
Observational (n=364)
No
Are circulating ω-3 polyunsaturated fatty acid levels associated with impaired left cardiac myocardial strain in hypertensive patients with preserved LVEF?
Higher circulating levels of specific ω-3 PUFAs are independently associated with impaired left cardiac myocardial strain in hypertensive patients with preserved LVEF, suggesting a potential risk of dysfunction and a need to avoid blind supplementation.
May signal higher strain risk in hypertension; leaves open causality and supplementation effects.
Objective To assess the association between circulating polyunsaturated fatty acids (PUFAs) and left cardiac myocardial strain in hypertensive patients using cardiac magnetic resonance feature tracking. Methods This retrospective study included 364 patients with preserved left ventricular ejection fraction (179 hypertensive, 185 controls). Left atrial (LA) and left ventricular (LV) strain parameters were derived from CMR images using CVI42 software. Group comparisons were performed using independent t-tests, ANCOVA, Mann–Whitney U tests, or chi-square tests as appropriate. Univariate and multivariable linear regression were used to examine associations between ω-3 PUFA levels and myocardial strain parameters. Logistic regression and ROC curve analysis were conducted to evaluate predictive value. Inter-observer agreement was assessed using intraclass correlation coefficients. Results After adjustment for age, sex, BMI, blood pressure, triglycerides, and creatinine, no significant differences in ω-3 PUFA levels or their subtypes were observed between groups (all p > 0.05). In hypertensive patients, docosapentaenoic acid (DPA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) were independently and negatively associated with multiple LV strain parameters, including mid-wall longitudinal strain, global radial strain, mid-wall radial strain, mid-wall circumferential strain, and apical longitudinal strain, as well as LA functional parameters, including reservoir strain and strain rate (all p < 0.05). Sex differences were noted: only DHA was negatively associated with apical radial strain in males, whereas DHA, DPA, and EPA were negatively associated with multiple LV basal and global strain parameters in females (all p < 0.05). ROC analysis showed DHA and DPA had moderate predictive value for LV dysfunction (AUC 0.613, 0.602), while DHA, EPA, and total ω-3 predicted LA dysfunction (AUC 0.612, 0.609, 0.629). Conclusion Blood ω-3 PUFA levels in hypertensive patients are independently associated with impaired left cardiac myocardial strain and increased dysfunction risk, an effect observed only in the hypertensive group. Different ω-3 subtypes demonstrate predictive value for left cardiac dysfunction. LV dysfunction is primarily associated with DHA and DPA, while LA dysfunction with EPA and total ω-3. Female patients are more sensitive to this effect. Blind ω-3 supplementation should be avoided, and sex-specific management strategies considered.
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Cui et al. (2026) conducted an observational in Hypertension (n=364). Circulating ω-3 polyunsaturated fatty acid levels vs. Control group (non-hypertensive patients) was evaluated on Left cardiac myocardial strain parameters (LA and LV strain). In hypertensive patients, circulating ω-3 polyunsaturated fatty acid levels were independently associated with impaired left cardiac myocardial strain, with total ω-3 predicting left atrial dysfunction (AUC 0.629).
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