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This is a Quantitative Study study.

Altered neurovascular coupling in drug-naïve first-episode major depressive disorder patients

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Analysis shows decreased neurovascular coupling in MDD patients, suggesting links to symptom severity and gender.

MDD patients show decreased global ALFF-CBF coupling, indicating potential neurovascular dysfunction.
Severe depression and female gender correlate with more pronounced neurovascular decoupling.
Altered ALFF-CBF coupling observed in several brain networks, including the default mode network and limbic system.
Findings imply that neurovascular decoupling could serve as a biological marker for MDD pathology.

Cai et al. (2025) studied this question.

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