This approach demonstrates successful simultaneous mapping of T1, T2, T2, T1rho, and PDFF in kidneys, suggesting enhanced diagnostic capabilities for diffuse kidney disease.
Motivation: Co-registered T1, T2, T2*, T1rho, and PDFF quantification could enable comprehensive characterization of renal tissue properties. Goal(s): To simultaneously collect T1, T2, T2*, T1rho, and PDFF maps in a 2D slice of the kidney in a single breath-hold. Approach: We implemented an MRF sequence featuring spin-lock preparations and a multi-echo rosette readout, designed for acquisition in a 20s breath-hold. Maps were generated from the acquired data using a low rank, dictionary-patch regularized reconstruction. Results: Joint 2D mapping of renal T1, T2, T2*, T1rho, and PDFF in a breath-hold is feasible, producing similar maps to conventional single-property approaches. Impact: An expanded rosette MRF protocol with spin-lock preparations for T1rho mapping, together with dictionary-patch regularized reconstruction, provides a multi-parameter quantitative evaluation of kidney health, potentially improving diagnostic accuracy for diffuse kidney disease.
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Griesler et al. (2025) studied this question.
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