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Assessment method shows neurovascular unit injury in rats after ischemia reperfusion injury, highlighting importance for clinical treatment.
Motivation: Exploring an MRI assessment method that offers a noninvasive way to monitor NVU damage after IS. Goal(s): To assess neurovascular unit (NVU) damage in cerebral ischemia reperfusion injury (CIRI) rats to provide a visual basis for clinical diagnosis and treatment of CIRI. Approach: Establishment of CIRI rats, multiparametric MRI combined with various histological techniques. Results: CIRI leads to NVU injury, blood-brain-barrier (BBB) disruption, and exacerbation of brain damage in rats. Multiparametric MRI combined with various histopathological techniques effectively assesses NVU injury after CIRI. Impact: The pathological hallmarks of acute ischemic stroke (AIS) are NVU damage and BBB destruction, and its clinical treatment has shifted from single neuron protection to NVU protection, which has become a new target for studying neuronal damage and protection mechanisms.
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Wang et al. (2025) studied this question.
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