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This is a Quantitative Study study.

Multi-parametric MRI evaluation of skeletal muscle alterations using FF, T1H2O, and T2H2O in healthy and pathological subjects

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Analysis shows six muscle clusters using fat fraction, water T1, and water T2, suggesting improved diagnosis of neuromuscular diseases.

Six muscle clusters were identified, with healthy controls classified in two distinct groups, and the rest found only in patients.
The study revealed a variable correlation between water T1 and water T2 among different muscle clusters present in subjects.
Using k-means clustering, 15 features were extracted from five muscle groups in both healthy and pathological settings to analyze muscle alterations.
Combining fat fraction and water T1 and T2 biomarkers enhances diagnostic precision for identifying muscle alterations and underlying conditions.

Marty et al. (2025) studied this question.

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