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September 17, 2025

3T vs 7T CEST contrast comparison in a prospective diagnostic study in glioma patients: insights into age dependence and tumor subtype sensitivity

Puntos clave

7T CEST shows stronger age dependence in normally appearing tissue than in tumors, suggesting age-related effects.
The study scanned 43 glioma patients, revealing that 7T offers limited advantages for tumor subtyping compared to 3T.
Analysis involved comparing CEST pool amplitudes in both normally appearing and tumor tissues across scanning fields.
Findings highlight the potential of 7T CEST in exploring age-related imaging changes, though mutation sensitivity remains inconclusive.

Resumen

Motivation: Chemical exchange saturation transfer (CEST) is a metabolic imaging tool increasingly used in glioma research. While 7T CEST offers superior chemical shift separation and SNR, 3T remains the clinical standard. Comparing these strengths can clarify CEST's diagnostic potential. Goal(s): To compare CEST contrasts at 3T vs. 7T in a glioma cohort, focusing on age dependence and tumor subtype sensitivity. Approach: We scanned 43 glioma patients at both 3T and 7T, analyzing CEST pools' Lorentzian amplitudes in normally appearing and tumor tissues. Results: Stronger age dependence appeared at 7T in normally appearing tissue, and not in tumor; IDH mutation sensitivity remains inconclusive across fields. Impact: This study shows that 7T CEST enhances age-dependent contrast but offers limited advantage for tumor subtyping over 3T, elucidating CEST's diagnostic potential. Future research can use age-related CEST changes at 7T to differentiate normal from pathological aging in clinical neuroimaging.

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