What question did this study set out to answer?

This research aims to identify molecular changes in gliomas using CEST imaging after radiotherapy.

April 1, 2026Open Access

Chemical exchange saturation transfer (CEST) imaging reveals tumor-specific molecular changes in adult gliomas after radiotherapy

Key Points

This research aims to identify molecular changes in gliomas using CEST imaging after radiotherapy.
Utilized CEST imaging to evaluate gliomas post-radiotherapy.
Compared CEST contrasts in tumor regions and normal-appearing brain tissue.
Monitored APTw-signal changes in progressive tumors versus pseudoprogression.
CEST contrasts remain stable in normal-looking brain tissue after radiotherapy.
Tumor-specific changes are detectable only through CEST, not conventional MRI.
The APTw-signal evolves differently in progressive tumors compared to pseudo-progression.

Abstract

Highlights CEST contrasts stay unchanged in normal-appearing brain of glioma patients after RT CEST contrasts reveal tumor-specific changes after RT not seen on conventional MRI APTw-signal evolves differently in progressive tumors compared to pseudoprogression Development of CEST contrasts in gliomas depends on the time point of examination

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