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Exploratory Multi-parametric Analysis of Biomarker Confirmed Alzheimer’s Disease Patients with Cognitive Impairment vs Normal Controls

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Reduced cerebral blood flow was noted in Alzheimer's patients compared to normal controls, highlighting diagnostic potential.
The top predictive metric for cognitive impairment was based on CEST, indicating its importance in Alzheimer's diagnosis.
Imaging methodologies included anatomic imaging, CEST, and arterial spin labeling, showcasing comprehensive MRI application.
Implementing MRI metrics could enable earlier intervention in Alzheimer's disease, potentially reducing healthcare costs.

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Exploratory analysis reveals MRI metrics differ in Alzheimer’s patients with cognitive impairment, suggesting stronger biomarkers.

Asturias et al. (2025) studied this question.

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