This research validates optimized hyperbolic secant pulse settings to enhance lipid quantification in brain tissue, suggesting improved reliability for transient noe measurements.
Motivation: In vivo lipid quantification in brain tissue is challenging due to limited uniform spin inversion with conventional adiabatic pulses, affecting transient NOE (tNOE) reliability. Goal(s): Optimize B1 amplitude of hyperbolic secant (HS) adiabatic pulses in tNOE to reduce magnetization transfer (MT) effects and improve lipid quantification repeatability. Approach: Validated optimized pulse parameters on a water phantom, then acquired repeatable tNOE maps in vivo, assessing white and gray matter contrast. Results: Optimized scanner voltage (305 V) produced high-quality tNOE contrast with minimal MT interference, showing CoVs of 1% for white and 3% for gray matter. Impact: This approach may improve lipid degeneration monitoring in neurodegenerative diseases like MS and Alzheimer's.
No takes yet. Share an insight, caveat, or question.
Benyard et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: