Study reveals neurovascular coupling disruptions in language and visual regions of children with spastic cerebral palsy, suggesting potential biomarkers.
Motivation: The relationship between cerebral blood flow (CBF) and neural activity, or neurovascular coupling (NVC), in spastic cerebral palsy (SCP) remains unclear, particularly its role in language and visual impairments. Goal(s): This study aims to investigate specific NVC disruptions in SCP to better understand associated cognitive and communication deficits. Approach: Twenty SCP children and 27 healthy controls underwent resting-state fMRI and arterial spin labeling to calculate regional NVC ratios, including CBF/fALFF, CBF/ALFF, CBF/ReHo, and CBF/DC. Results: SCP children exhibited significant NVC disruptions, with reduced coupling in the superior temporal gyrus and increased coupling in the calcarine and lingual gyri. Impact: This study identifies distinct NVC patterns in SCP, providing potential biomarkers for assessing disease severity and guiding targeted interventions for SCP-related impairments.
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Yu et al. (2025) studied this question.
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