Resting state neurovascular coupling patterns estimated using advanced multiband multi-echo BOLD/ASL imaging

Impaired neurovascular coupling (NVC) plays a critical role in many neurovascular pathological processes. Several resting state fMRI methods have been used to estimate NVC including BOLD/CBF coupling and, to a lesser extent, ALFF and fALFF. In this study, resting state BOLD/CBF coupling was evaluated using advanced multiband multi-echo BOLD/ASL sequence and correlated with ALFF and fALFF in healthy volunteers. Significant correlation between BOLD/CBF coupling and ALFF and fALFF was seen in major brain network hubs. These results indicate MBME BOLD/ASL may provide similar, but complimentary measures of NVC compared to traditional RS metrics.