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This is a Quantitative Study study.

Neurovascular Uncoupling in Mild Cognitive Impairment: Insights from Multiband Multi-echo BOLD-Perfusion Imaging

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BOLD-CBF coupling was significantly lower in individuals with mild cognitive impairment compared to controls.
Reduced coupling was observed specifically in brain areas like the precuneus and visual cortex.
Multiband multi-echo imaging techniques were used to assess brain-blood flow dynamics effectively.
These findings highlight the need for further investigation into the physiological mechanisms underlying the disruption.

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Observational analysis revealed reduced BOLD-CBF coupling in mild cognitive impairment, suggesting neurovascular disturbances.

Cohen et al. (2025) studied this question.

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