Assessing Gravity’s Impact on Choroid Plexus Position with 1.5 T Rotatable Superconductive Cryogen-free MRI

Motivation: Few studies have explored the morphology of choroid plexus in a natural upright posture. Goal(s): This study aims to investigate whether the position of the choroid plexus changes in response to gravity when comparing supine and upright scanning postures. Approach: Twenty-seven healthy young volunteers were scanned using a 1.5 T rotatable MRI at pitch angles of 0 and 90 degrees. Gap lengths in different directions were measured on segmented images between the choroid plexus and ventricles. Results: A significant downward shift in the choroid plexus position was observed along the direction of gravity, while changes along other axes were minimal. Impact: This study reveals the gravitational influence on the position change of the choroid plexus and demonstrates its morphology in a typical standing condition. These findings could have implications for future research on CSF exchange and flow in different postures.