MRS Insights into Cerebellar Alterations and Motor Variations in Welders Exposed to Manganese

Motivation: Occupational Manganese (Mn) exposure is linked to neurotoxicity, yet its impact on cerebellar motor control and metabolism remains unexplored. Goal(s): In this study, we aim to determine if Mn cumulative exposure levels can be predictive of neurotoxicity identified through changes in GABA, GSH, and/or Glu concentrations and motor functions. Approach: Participants underwent MRS and Neuropsychological testing. Correlations between metabolites, Mn exposure and Motor functions were examined. Results: Mn exposure was associated with increased motor scores (rigidity, tremor) and metabolite changes, notably elevated Glx and reduced GSH, indicating oxidative stress and excitatory imbalance. Impact: This study examines the cerebellum's response to Mn overexposure, linking elevated Mn to disrupted glutamatergic signaling and potential oxidative stress. Findings could support stricter occupational health guidelines and further research on Mn's effects on motor control and neurodegenerative risks.