Chronic exposure to Mn and Fe, through inhalation of welding fumes, is known to cause neurotoxicity. In this MRS study, we aim to determine if toenail Mn and Fe levels can be predictive of neurotoxicity identified through changes in GABA, GSH, and/or Glu concentrations. Significant GABA and GSH correlations with Fe indicate that toenail Fe concentrations can reflect decreased GABA and GSH levels in the welders’ brain. This emphasizes that Fe should not be ignored and might contribute to oxidative stress in Mn neurotoxicity.
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Nossa et al. (2024) studied this question.
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