Development of a Scoring System for Predicting the Benign-Malignant Degree of IPNB Based on Imaging Features and Clinical Indicators

Motivation: The Intraductal Papillary Neoplasm of the Bile Duct (IPNB) is a macroscopic and precancerous lesion typically characterized by papillary or villous proliferation within the bile ducts. Goal(s): Our study aims to establish a scoring system to predict the benign and malignant degree of IPNB. Approach: Nomogram model based on imaging and clinical features was used to predict the malignant potential of IPNB. Results: The nomogram model achieved an AUC of 0.855 (95% CI: 0.801-0.908) in the training set (threshold: 0.431, sensitivity: 0.879, specificity: 0.745) and an AUC of 0.912 (95% CI: 0.846-0.977) in the testing set (threshold: 0.446, sensitivity: 0.974, specificity: 0.783). Impact: The scoring system demonstrates high sensitivity and specificity in predicting IPNB malignancy. This scoring system, based on clinical data and imaging features, enables early IPNB screening and surgical planning.