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Longitudinal Validation of Quantitative T1 MRI Measurements: A Six-Year Multi-Site Analysis Using the ISMRM/NIST Reference System

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T1 values remained consistently within ±5% of reference standards across all sites and over time, affirming reliability.
Inversion-recovery T1 mapping showed low inter-site variability, strengthening support for quantitative MRI protocols.
This longitudinal validation emphasizes the clinical relevance of standardized T1 relaxometry for disease monitoring.
Results imply that robust quantitative T1 mapping can facilitate reliable measurements in multi-center clinical settings.

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Longitudinal study assesses T1 relaxometry consistency across 11 centers, indicating reliable measurements.

Martinez et al. (2025) studied this question.

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