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This is a Quantitative Study study.

50 Years after Relaxometry: The Performance of Three Quantitative MRI Methodologies in the Real World

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Significant variability in T1/T2 values was found across three methodologies, and this impacts clinical applications.
Standardized imaging protocols are essential to ensure comparability in relaxometry studies for accurate outcomes.
Using healthy volunteers and MRI phantoms, we assessed the stability of quantitative MRI methodologies.
The need for rigorous data screening is underscored to minimize bias and enhance T1/T2 imaging analysis.

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Systematic comparison reveals variability in T1 and T2 values across methodologies, indicating the need for standardized protocols.

Zhao et al. (2025) studied this question.

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