Implementation of a breath-held 4D MUSIC MRI pulse sequence demonstrates feasibility in adults with structural heart disease, indicating wider applications beyond children.
Motivation: Practical drawbacks of 4D and 5D MR techniques for imaging of structural heart disease pose significant barriers to the widespread adoption of multi-dimensional approaches in clinical practice. Goal(s): To implement 4D-MUSIC in a single breath-held acquisition with immediate inline reconstruction, and to assess its feasibility in adult patients. Approach: A single breath-held 4D cardiac phase-resolved (BH 4D-MUSIC) ferumoxytol-enhanced MRI pulse sequence was implemented and its feasibility in adult patients with structural heart disease was evaluated. Results: BH 4D-MUSIC was successfully acquired and reconstructed inline in all patients, with breath hold durations range of 17-24 seconds and 8-16 cardiac phases. Impact: Ferumoxytol-enhanced single breath-held 4D MUSIC is feasible, extending its potential applications beyond children under anesthesia to adults and older children with cardiovascular disease.
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Finn et al. (2025) studied this question.
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