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September 17, 2025Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

Long-Term Effects of Linear versus Macrocyclic Gadolinium-Based Contrast Agents on Gene Expression in the Central Nervous System of Mice

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Authors

CWchuanbing wangSWS. Wang

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Overview

This research reveals changes in gene expression linked to linear gadolinium-based contrast agents in mice, suggesting neuroinflammatory effects.

Key Points

  • Chronic exposure to linear gadolinium-based contrast agents significantly alters gene expression in mice, affecting neuroinflammatory pathways.
  • RNA sequencing revealed notable gadolinium retention with linear GBCAs, indicating potential long-term effects on the central nervous system.
  • Investigating gadolinium's impact involved analyzing genetic changes in the central nervous system via detailed RNA sequencing.
  • Findings underscore the importance of further studies to evaluate the long-term safety of linear gadolinium-based contrast agents.

Cite This Study

wang et al. (2025) studied this question.

synapsesocial.com/papers/68d4597b31b076d99fa5ccf5https://doi.org/10.58530/2025/0773
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gadolinium Presence in the Brain After Gadolinium-based Contrast Agents2026
  2. 2Cerebral Accumulation of Gadolinium (Gd3+) and Related Cellular Stress Pathways in Rat Brain Tissue2026
  3. 3Deposition of Gadolinium in the Central and Peripheral Nervous Systems and Its Effects on Sensory, Cognitive, and Athletic Implications after Multiple Injections of Gadolinium-Based Contrast Agents in Rats2024 · 6 citations
  4. 4CONTROVERSIAL ISSUES REGARDING THE USE OF GADOLINUM-BASED CONTRAST AGENTS – THE LATEST REPORTS2025
  5. 5Toxicity Mechanisms of Gadolinium and Gadolinium-Based Contrast Agents—A Review2024 · 74 citations