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March 7, 2026TomographyOpen Access

Cerebral Accumulation of Gadolinium (Gd3+) and Related Cellular Stress Pathways in Rat Brain Tissue

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Authors

GTGöksel TuzcuBÇBurak ÇildağSÇSongül Çildağ

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Overview

Experimental study analyzes Gd3+ accumulation and cellular stress in rat brains after GBCA exposure, indicating potential risks.

Key Points

  • The study aims to investigate the accumulation of gadolinium in the brain and its effects on cellular stress responses in rats exposed to gadolinium-based contrast agents.
  • Controlled experimental study in male Sprague-Dawley rats
  • Exposed rats to gadolinium-based contrast agents for 24 and 72 hours
  • Measured Gd3+ levels and stress markers postmortem in basal ganglia tissue
  • Linear GBCA resulted in persistent Gd3+ levels over time
  • Significant reduction in Gd3+ levels was observed in macrocyclic GBCA-treated rats from 24 to 72 hours (p < 0.001)
  • Elevated expressions of PERK, DDIT3, and ATF6 in linear GBCA group (p < 0.05)

Cite This Study

Tuzcu et al. (2026) studied this question.

synapsesocial.com/papers/69abc2725af8044f7a4ec0a0https://doi.org/10.3390/tomography12030037
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long-Term Effects of Linear versus Macrocyclic Gadolinium-Based Contrast Agents on Gene Expression in the Central Nervous System of Mice2025
  2. 2Gadolinium Presence in the Brain After Gadolinium-based Contrast Agents2026
  3. 3Gadolinium and gadoteric acid single exposure – long-term impact on the kidney’s gene expression2026
  4. 4Single exposure to gadolinium or gadoteric acid – influence on metal elements levels in blood, kidney and brain2026
  5. 5Quantitative Analysis of Gadolinium Deposits in Liver Tissue of Patients After Single or Multiple Gadolinium-based Contrast Agent Application2025