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May 7, 2026Science LettersOpen Access

Single exposure to gadolinium or gadoteric acid – influence on metal elements levels in blood, kidney and brain

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Authors

SCSusana CoimbraUniversidade do PortoSRSusana RochaRARui AzevedoUniversidade do Porto

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Implication

Exposure to gadolinium alters copper and zinc levels in blood and kidney, indicating potential toxicity.

Key Points

  • To evaluate the effects of gadolinium and gadoteric acid on metal elements in blood, kidney, and brain.
  • Conducted an experimental study with male Wistar rats divided into 3 groups (n=10 each)
  • Administered a single dose (0.1 mmol/kg) of gadolinium, gadoteric acid, or control vehicle
  • Evaluated metal levels in blood, kidney, and brain at two time points: 2 days and 20 weeks post-exposure using ICP-MS.
  • Gadolinium significantly increased blood levels of copper and manganese shortly after exposure
  • Long-term exposure to gadolinium elevated zinc and molybdenum levels in the kidney
  • Gadoteric acid had minimal impact on metal levels, with decreased manganese in the brain observed short-term.

Cite This Study

Coimbra et al. (2026) studied this question.

synapsesocial.com/papers/69fbe357164b5133a91a29e2https://doi.org/10.48797/sl.2026.418
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1#1613 Gadolinium and gadoteric acid's short-term impact on kidney function and lipid profile2024
  2. 2Gadolinium and gadoteric acid single exposure – long-term impact on the kidney’s gene expression2026
  3. 3#1502 Short-term effects of gadolinium and gadoteric acid on kidney — impact on inflammation2024
  4. 4The effect of iron status on gadolinium deposition in the rat brain: mechanistic implications2024
  5. 5Abstract 2211 Differential interactions of Gd with key mammalian lipids contained in brain membranes affect liposome fluidity and size2024